Methylation Map – Interactive PDF (Practitioner Edition)

⭐ New v1.5 Release: The World’s Most Advanced Methylation Teaching Tool

(Includes Practitioner Insight PDFs + Pop-Up Clinical Guides)

A professional-grade interactive pathway map with 150+ clinical pop-ups, Practitioner Insight PDFs, and full-cycle integration across Methylation, Neurotransmitters, Sulfur Detox, Histamine Pathways, and the entire Krebs Cycle. Instant digital download.

Current Version: v1.5 • All purchasers receive free v1.x updates.

⭐ Introductory Release Price – Limited Time

Retail Price: $1,497
Introductory Practitioner Price: $749

What You’re Getting

This tool connects the Methionine, Folate, BH4/Neurotransmitter, Urea, Transsulfuration, and Krebs cycles into one seamless, clinician-focused teaching experience. Every node opens into a pop-up with enzyme overviews, nutrient cofactors, inhibitors, clinical blocks, symptom patterns, and decision-making cues.

Many pop-ups now include full Practitioner Insight PDFs, offering deeper explanations on topics like:

• Methylfolate trapping
  
• Over-methylation vs. under-methylation
  
• Histamine pathways (HNMT vs DAO vs ECL)
  
• CBS, SUOX, H₂S, and sulfur intolerance
  
• Taurine vs cysteine and sulfur overload
  
• Homocysteine dynamics & the SAM:SAH ratio
  
• PEMT, GAMT, AHCY, BHMT, and more

This is the only tool available that shows all interconnected cycles interacting in real time with clinical interpretation built directly into the structure.

Why Practitioners Love It

• Clarity in minutes: Demonstrate how a single enzyme slowdown (DHFR, MTHFR, CBS, MAO-A, COMT, NOS…) ripples across mood, energy, detox, hormones, and inflammation.
• Layered depth: Click any node to reveal the full story pop-ups and Practitioner Insight PDF's, enzyme context, and clinical cues only when needed.
• Perfect for case reviews and consults: Open during sessions to walk students or clients through methylation issues, interpret labs, illustrate pathways, or plan protocols with visual context.

A Complete System: Not Just a Diagram

This is now a core education tool used by clinicians to teach:

• Under- and over-methylation
  
• BH4 depletion and neurotransmitter imbalances
  
• Nitric oxide uncoupling
  
• Sulfur congestion & H₂S toxicity
  
• Histamine intolerance (systemic vs food vs gastric)
  
• Oxidative stress
  
• Detoxification dynamics
  
• Krebs energy deficits driving methylation blocks
  

What’s Inside

1. Core Metabolic Cycles Integrated Into One System

• Methionine Cycle
• Folate Cycle
• BH4 / Neurotransmitter Cycle
• Urea Cycle
• Transsulfuration Pathway
• Full Krebs Cycle with intermediates popups

2. 150+ Interactive Pop-Ups

• Every metabolite and enzyme includes:
• Function & flow direction
• Nutrient cofactors
• Botanical/nutrient inhibitors
• SNP relevance (when clinically meaningful)
• Clinical clues & decision points

3. Practitioner Insight PDFs (embedded inside pop-ups)

Deep-dive guides covering:

• Overmethylation
• Undermethylation
• Methylfolate trapping
• Histamine pathways: HNMT vs DAO vs ECL
• Taurine vs cysteine & sulfur overload
• CBS / SUOX / H2S physiology
• AHCY, PEMT, GAMT interpretations
• SAM:SAH ratio analysis
• And more (continuously expanding)

4. Neurotransmitter & Nitric Oxide Integration

Clickable explanations of:

• Serotonin, dopamine, norepinephrine, epinephrine
• GABA, glutamate, melatonin
• BH4 as a neurotransmitter “spark plug”
• NOS coupling vs uncoupling
• ADMA, arginine, citrulline pathways

5. Clinical Concepts Embedded Throughout

• Methylation flow vs Methylation load
• Redox imbalance
• Energy deficits blocking Methylation
• Hormone detox (estrogen, catechol estrogens)
• Cardiovascular risk mechanisms
• Gut–brain–liver interconnection
• Histamine intolerance frameworks
• SIBO/SIFO/SIMO links to sulfur metabolism